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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Beta-Nicotinamide adenine dinucleotide hydrate, commonly referred to as β-NADH, is the reduced form of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells. β-NADH plays a vital role in cellular metabolism, primarily functioning as a carrier of electrons and hydrogen ions in redox reactions.
Within the cell, β-NADH participates in several key metabolic pathways, including glycolysis, the citric acid cycle, and oxidative phosphorylation. In these processes, it serves as a crucial electron donor, facilitating ATP production and providing energy for cellular functions.
Additionally, β-NADH is involved in various enzymatic reactions, serving as a coenzyme for a diverse range of enzymes, including dehydrogenases and reductases. Its role as a coenzyme enables the catalysis of a multitude of biochemical reactions, such as the breakdown of nutrients and the synthesis of macromolecules.
Research has also focused on the potential therapeutic applications of β-NADH, particularly in the context of mitochondrial function, energy metabolism, and neurodegenerative disorders. Studies have explored its role in improving cellular energy production, protecting against oxidative stress, and potentially mitigating the effects of certain neurological conditions.
In summary, β-NADH is an essential coenzyme involved in cellular energy production, redox reactions, and enzymatic processes. Its significance in cellular metabolism and its potential implications for therapeutic interventions highlight its importance in understanding fundamental biological processes and exploring potential treatment strategies.
Application
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | NAD+ |
| CAS: | 53-84-9 |
| MF: | C21H27N7O14P2 |
| MW: | 663.43 |
| EINECS: | 200-184-4 |
| Product Categories: | nucleoside;Biochemistry;Enzymes and Coenzymes in Nucleic Acids;Nucleosides, Nucleotides & Related Reagents;Vitamin Related Compounds;Vitamins;Bioproducts;Cofactor;Inhibitors;53-84-9 |
| Mol File: | 53-84-9.mol |
| Melting point | 140-142 °C (decomp) |
| alpha | D20 -31.5° (c = 1.2 in water) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | Powder |
| color | White |
| PH | ~3.0 (50mg/mL in water) |
| Odor | Odorless |
| Water Solubility | Soluble in water at 50mg/ml |
| Merck | 14,6344 |
| BRN | 3584133 |
| Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| EPA Substance Registry System | Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-84-9) |
| Hazard Codes | Xn,F,Xi |
| Risk Statements | 36-68/20/21/22-20/21/22-40-22 |
| Safety Statements | 36-26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS | UU3450000 |
| TSCA | Yes |
| HS Code | 29349990 |
| Description | β-Nicotinamide adenine dinucleotide (NAD+) plays a major role in metabolism as a cofactor and mobile electron acceptor. NAD+ is a required oxidizing cosubstrate for many enzymes. It is reduced to NADH (Cat# N-035) which carries electrons to the electron transport chain for subsequent oxidative phorphorylation and ATP production. NAD+ is capable of donating ADP-ribose moieties to a protein, producing nicotinamide in the process. Sirtuin enzymes use NAD+ as a substrate to deacetylate proteins and direct activity between the nucleus and mitochondria. NAD+ is regenerated by fermentation and by oxidative phosphorylation. |
| Chemical Properties | Beta-Nicotinamide adenine dinucleotide is a hygroscopic white powder. It should be stored desiccated. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20°C. |
| History | The coenzyme NAD+ was first discovered by British biochemists Arthur Harden and William John Young in 1906. They observed that the addition of boiled and filtered yeast extract significantly increased the rate of alcoholic fermentation in unboiled yeast extracts. They named the unidentified factor responsible for this effect a coferment. By extensively purifying it from yeast extracts, Hans von Euler-Chelpin identified this heat-stable factor as a nucleotide sugar phosphate. In 1936, German scientist Otto Heinrich Warburg demonstrated the role of this nucleotide coenzyme in hydride transfer and determined the nicotinamide portion as the site of redox reactions. Vitamin precursors of NAD+ were first identified in 1938, when Conrad Elvehjem showed that liver has an "anti-black tongue" activity in the form of nicotinamide. Then, in 1939, he provided the first strong evidence that niacin is used to synthesize NAD+. |
| Uses | β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. |
| Application | β-Nicotinamide adenine dinucleotide (β-NAD) is a cofactor of alcohol dehydrogenase and acts as a neuromodulator and an inhibitory neurotransmitter in visceral smooth muscles. The NAD/NADH ratio has a role in the regulation of intracellular redox potential. It thereby influences metabolic reactions in vivo. It has been used for the preparation of deacetylated tubulin. It has also been used for UDP-glucose-6-hydrogenase (UGDH) enzyme activity assay of orital fibroblast cell lysates. β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). |
| Definition | ChEBI: β-Nicotinamide adenine dinucleotide (NAD) is the oxidized form of β-Nicotinamide Adenine Dinucleotide. It exists as an anion under normal physio-logic conditions. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+). It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| benefits | The benefits of NAD+Therapy directly related to mental health treatment include: Restores cellular energy, metabolism and promotes cellular repair Helps regulate cellular defense and reduces inflammation Elevates mood and generates the feeling of calmness and happiness Supports healthy aging and cognitive function NAD infusion therapy is most effective when multiple infusions are conducted regularly over time. Long-term maintenance and cellular support contribute to less overall damage to your mitochondria, a slower aging rate, and better cognitive health. |
| General Description | β-Nicotinamide adenine dinucleotide (NAD) is a ubiquitously found electron carrier and a cofactor. NAD+ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD+ complexes, the enzyme-cofactor interactions are highly conserved. |
| Biological Activity | NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH. NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein. |
| Biochem/physiol Actions | β-Nicotinamide adenine dinucleotide (β-NAD) is an electron carrier and a cofactor, significantly involved in enzyme-catalyzed oxido-reduction processes and many genetic processes. NAD cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. NAD is also involved in microbial catabolism. β-NAD acts as a substrate for various enzymes in several cellular processes. |
| Side effects | In the studies conducted thus far, people taking between 1000mg-2000mg per day have reported zero long term side effects. However, during the active infusion, some people may feel temporary nausea or stomach discomfort. |
ซัพพลายเออร์ที่มีใบอนุญาตการทำธุรกิจ
