หมายเลข CAS: | 906673-24-3 |
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สูตร: | C14h10bno3 |
EINECS: | 815-051-1 |
พิมพ์: | สื่อกลางด้านเภสัชกรรม |
ลักษณะภายนอก: | ผงแป้ง |
คุณภาพ: | ด้านเทคนิค |
ซัพพลายเออร์ที่มีใบอนุญาตการทำธุรกิจ
Product Name: Crisaborole
Synonyms: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzoni trile AN 2728;AN-2728, >=98%;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzoni trile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzoni trile
CAS: 906673-24-3
MF: C14H10BNO3
MW: 251.05
EINECS: 815-051-1
Melting point: >130°C
Boiling point: 425.9±55.0 °C
Density: 1.33±0.1 g/cm3
Storage temp.: room temp
Appearance: White powder
Description:
Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.
Uses:
A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent.
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.
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Shipping time | 3-7 working days (Door-to-Door) |
After-sale service | 24/7 Online for any problems |
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Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei
ซัพพลายเออร์ที่มีใบอนุญาตการทำธุรกิจ